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Contact your GP if you experience: Persistent or worsening reflux symptoms that do not improve with lifestyle modifications or over-the-counter remedies after two weeks Difficulty swallowing (dysphagia) or a sensation of food sticking in the chest Unintentional weight loss beyond what is expected from diabetes management Persistent nausea or vomiting that prevents adequate food or fluid intake Signs of dehydration including dark urine, dizziness, or reduced urination Right upper abdominal pain, fever or yellowing of the skin/eyes , which could indicate gallbladder diseasea known risk with GLP-1 receptor agonists According to NICE guideline NG12, certain symptoms require urgent specialist referral (within two weeks), including: Dysphagia (difficulty swallowing) at any age If you're aged 55 and over with weight loss and upper abdominal pain, reflux, or dyspepsia Seek immediate medical attention (A&E or call 999) if you develop: Severe, persistent abdominal pain , particularly in the upper abdomen radiating to the back, which could indicate pancreatitisa rare but serious side effect of GLP-1 receptor agonists Vomiting blood or passing black, tarry stools, suggesting gastrointestinal bleeding Severe chest pain that could represent cardiac issues rather than simple reflux Your GP may need to review your medication regimen if side effects are significantly impacting your quality of life

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Glutathione is needed for phase 2 detoxification in the liver

An increased GSSG-to-GSH ratio is considered indicative of oxidative stress